Need to explore the hot melt extrusion
see:
http://files.pharmtech.com/alfresco_images/pharma/2016/06/20/e92d88ea-bca7-4360-8cdd-0f3010f25961/PT0616%20Thermo%204-14%20HotMelt%20DD%20pr2f-Digital.pdf
also you can request some papers at researchgate:
Article A Review of Hot-Melt Extrusion: Process Technology to Pharma...
Article Scale-up challenges in hot-melt extrusion: Critical issues t...
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