Streptozotocin injection produces diabetes within two days, but this is considered as acute diabetes. I want to know that after how many days these streptozotocin injected rats can be considered as chronic diabetic model similar to human diabetes.
I never seen anything in the literature that gives an exact timeframe for acute vs chronic. Just simply that acute is short term and chronic is long term. Sorry I cannot be more helpful.
A good length of time is at least 4 weeks after blood glucose rises to 300-400 mg/dL. Rats are tough and can remain generally healthy for many weeks (Roberto Zatz did some very long experiments in the 80s, some over a year). The way to manage this is to define strict criteria before you start, and use that.
As far as replicated human diabetes, I still don't know whether or not we can very accurately. It depends on what kind of features or injury you are looking for. For example, renal damage is hard to get in a typical "outbred" strain of rat at any duration of diabetes.
In the end you need to carefully look through the lit of your particular field to see what happens over the time course of diabetes in rats with respect to the systems you're studying. That will give you a good indication of what sort of timeline you should use. That said, a good starting point would be a minimum of 4 weeks of diabetes. Of course make sure these animals receive supplemental insulin so glucose doesn't go to high, and so the animals don't lose weight, since both of these are serious confounding factors.
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