Hello everyone,
I'm working on a new line of transgenic mice. Since 2 weeks now, when I take the mutant animals in my hands, they have small spasms and make small cries. It does not look like seizures : no jump no tetanic crisis.
I don't know what it can be? if anyone has ever seen this before or has an idea ?
thank you for your help
best
I am not sure if I will be answering your question but I will give it a try. In patients with epileptic spasms as well as myoclonic jerks, there might be a contraction of the diaphragm (as a muscle) and this will give the cry sound. Sometimes the spasms might be minimal and only involve small areas like eyes only ( so in your case those might be minor spam affecting the diaphragm ).
Maite M. Moreau most probably there is an alteration in physiological, biochemical and molecular properties reflective of a fast fibre phenotype in the transgenic mice due to induced expression of some protein in the slow twitch muscle
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