Can someone explain the best way to determine the dose of extract to be administered to experimental animals in evaluating its potency ?
Your response will be highly appreciated.
vous devez prendre en considération la toxicité de l'extrait et les tests in vitro. par exemple si vous étudiez l'effet antibactérien de vos extrait. la dose à administrer doit être inférieur à DL50 et supérieure à la CMI (Concentration minimale inhibitrice). il faut aussi se baser sur les études antérieures.
you must take into consideration the toxicity of the extract and the in vitro tests. for example if you study the antibacterial effect of your extract. the dose to be administered must be less than LD50 and greater than the MIC (Minimum Inhibitory Concentration). it must also be based on previous studies.
Dr khadidja. Much appreciated. Moreover, can't the dose just be determined by considering only some references or as used in some publications without evaluation of the LD50.
Thanks in advance.
And is there a crime for the aforementioned above?
2. What ratio or percentage of the LD50 must be used in the administration..
Regards.
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