hi all, anyone had idea that any bacterial infection particularly H.pylori on cell lines(innate immune cell lines like-THP-1, Raw264.7, U937) or any other cal lead to complete repression and activation of genes.

In my transcriptome analysis in which we have treated raw 264.7 H.pylori at 1.10 MOI for 6 hrs , there is complete repression or activation of many genes.

I wonder is it possible??