if we want to compare this polymer versus polyvinylpyrrolidone, which one is better to use as a thermosensitive polymer capable to transport a hydrophobic drug to a cell?
Sorry in advance, my answer will not be exhaustive.
1. In mildly acidic media such as in lisosomes (pH about 4.5 - 5.5), N-vinylcaprolactam monomer units will neither hydrolyse (since amide bond does not hydrolyze even in 95% trifluorocetic acid for hours) nor protonate (since nitrogen is “part” of amide group). The same works for poly(N-polyvinylpyrrolidone).
2. Regarding drug loading – I would prefer poly(N-vinylcaprolactam) since it is more amphiphilic than poly(N-polyvinylpyrrolidone); but I cannot say anything valuable on their thermoresponsiveness.
Hi,
In the pH range of 4.5-5.5, vinylcaprolactam will not hydrolyse.
I would also prefer Polyvinylcaprolactam for drug delivery application.
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