About the intramolecular electron transfer pathway in a dehydrogenase?

23 August 2019 1 5K Report

A dehydrogenase from halophilic bacteria was a flavoprotein with FAD as its prothetic group, and its activity was dependent on the presence of NAD+ or NADP+.We speculate that the electron was tansferred from the substrate to NAD(P)+ bound on the enzyme, then to FAD to reduce the flavin? Could the electrons were directly transferred to NAD(P)+, then to FAD? Is it possibly?

Pedro J Silva

It depends on the distance between the flavin and the nicotinamide, but I would think it is possible (e.g. as in pyruvate dehydrogenase) . Do you happen to know the sequence or structure of your dehydrogenase?

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