Dear Farahnaz Faraji, please check the following free access RG document. My Regards

https://www.researchgate.net/publication/316167512_Polymeric-nanoparticles_Influence-of-polymer-surfactant-and-composition-of-manufacturing-vehicle-on-particle-size

Dear Farahnaz Faraji, please check the following free access RG document. My Regards

https://www.researchgate.net/publication/316167512_Polymeric-nanoparticles_Influence-of-polymer-surfactant-and-composition-of-manufacturing-vehicle-on-particle-size

Heaps of thanks Dr Farahnaz Faraji, How Fascinating!!! It is very interesting question.

Kind Regards

Farahnaz Faraji , many factors can play an significant effect on this case, such as increasing the concentration of polymer obtains the optimal ratio between polymer and crosslinker, surfactant, another polymer in formulation etc.

actually you can find many cases in my article with its discussion

Article Alginate Nanoformulation: Influence of Process and Selected Variables

@hazem choukaife

Thanks for sharing your valuable information

Farahnaz Faraji As Hazem Choukaife said it depends on several parameters to reduce the size of NPs; however, in case of weight ratio of polymers, it depends on nature of them such as functional groups that lead the reaction to form particles.