Vaccines

A forum for discussion on vaccine development, delivery, manufacturing, research, and formulation. | Review and cite VACCINES protocol, troubleshooting and other methodology information | Contact experts in VACCINES to get answers

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Questions related to Vaccines

Can anybody suggest how vaccines designed against intracellular pathogens could shape memory CD8 T cell subsets?

I need to know how the prime-boost vaccines design for intracellular pathogens can generate different subsets of memory CD8 T cell. Vaccines for intracellular pathogens are too difficult because...

23 October 2014 5,131 6 View

Is there any association between H.pylori and development of autoimmune disorders?

H.pylori and autoimmune diseases

24 September 2014 3,210 7 View

Can anyone suggest a molecular method to detect the presence of influenza virus in human body?

Not everyone who becomes infected with INFLUENZA gets sick. We don’t need any special molecular approach to detect influenza when people got really sick. But many people may feel good even if they...

23 September 2014 6,605 10 View

What are the international conventions for the extension of a vaccine?

Ebola disease is much death in some parts of Africa. There is no vaccine to treat the disease. American experts are treated with serum.

25 August 2014 7,087 3 View

What is the hope with the current vaccine candidates against tuberculosis after disappointing results of phase 2b of the MVA85A?

Efficacy and effectiveness of BCG are mostly debated since decades so the urgent need of a new TB vaccines. To date, among 12 candidates in the pipeline, only one ( MVA85A ) has reached the phase...

08 August 2014 363 6 View

Is it necessary to separate stimulator cells from splenocytes after in-vitro stimulation before performing CTL assay?

I tried to perform CTL assay with mice splenocytes without seperating them from the stimulator cells. Mice breast cancer cell line (4T1 ) was stably integrated with the target antigen and the...

07 July 2014 3,382 2 View

Can anyone give advice on Fenton reaction inhibition in M. tuberculosis?

I am investigating the mechanism of action of a cationic peptide against MTB. I suspect one of the mechanisms is by the Fenton reaction. One way I would like to prove this is by use of thiourea...

29 June 2014 3,392 6 View

Have you been in West Africa during the Ebola outbreak(s)?

I am looking for people who are in, or have recently returned from, the areas of West Africa affected by the current Ebola outbreak, as I would like to interview them regarding their health...

25 June 2014 8,850 2 View

How many epitopes are necessary in a vaccine?

Are 2 with the highest scores enough? I have cloned a fragment of a protein which includes two epitopes with the 2 highest scores, 1 and 0.845, the epitopes recommended by the software. The other...

24 May 2014 4,963 7 View

Is there any vaccine under clinical trails to treat Diabetes Mellitus?

I had searched in database about my new review relating vaccines to fight against Diabetes and I found two vaccines under clinical trail, but I am enable to find more information relating to it....

01 May 2014 4,206 2 View

Are recombinant allergens the future of the immunotherapy for treating allergic diseases?

In the last two decades, dozens of recombinant allergens have been produced in different organisms. However, the quality of them remains uncertain due to the absence of real specifications,...

18 January 2014 2,055 4 View

Does anyone know a protein array that harbors many different protein-ag from various bacteria and viruses on one chip?

I would like to study the cross-reactivity of antibodies affinity-purified from patients with a certain autoimmune disease.

17 January 2014 6,327 1 View

What are the most suitable liquids to take medication with and does it really matter?

I was recently part of a discussion, where it was stated, that taking oral medication with anything else than water, will decrease its effectiveness due to the chemical reactions. What are your...

21 October 2013 4,842 6 View

Does anyone have experience with oral immunotherapy for patients with IgE mediated food allergy?

Safety and efficacy

03 September 2013 6,488 1 View

Why is so hard to find a vaccine for Ebola Virus?

Although the ebola virus causes a very severe illness, affects multiple organs in the body and is often accompanied by hemorrhage, MODS etc... nor NIAID nor other facilities find a veritable cure...

29 August 2013 462 11 View

Do those of you who offer the BCG vaccine to their NICU graduates have specific guidelines applicable to preterm infants?

We were used to offer BCG vaccine to healthy term infants upon discharge from the birth hospital. When it comes to preterm ones the discharge point was used as an acceptable cutoff point. However,...

18 August 2013 221 7 View

Can someone help me find a data set for FMDV (foot-and-mouth disease virus) and any computer science publications about that point?

...

23 May 2013 6,085 6 View

What is your opinion about the severity of the H1N1 season 2012-2013

Reviewing the last weeks, we observed at least 4 cases of severe respiratory failures -ARDS in patients diagnosed with H1N1. Is this seasonal flu more dangerous than the years before or is my...

18 February 2013 4,757 2 View

Does Viral Hemorrhagic Septicemia Virus (VHSV), inactivated with formalin (0.3%) and stored at 4 degree C lose its antigenic property ?

Antigenic property of Viral Hemorrhagic Septicemia Virus (VHSV)

16 January 2013 3,853 8 View

What do you think is the best method to analyse hCG except biological assays?

Having gone through your publication on quantitative analysis of hCG, when there is much difference in the results from different systems - what is the best method to analyse it?

15 December 2012 7,643 9 View

Does IFNβ play a role in proinflammation?

We know that the IFNβ is often used as an anti-inflammatory. Does IFNβ play a role in proinflammation? Especially in autoimmunity?

17 August 2012 6,295 9 View

How can extending Reverse Vaccinology be helpful in developing a new Antigen?

The basic idea behind Reverse Vaccinology is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes. Next, those genes are filtered for desirable attributes...

17 July 2012 9,878 5 View

Which kind of cell line should be used in the study of rheumatoid arthritis?

Any public literature?

08 May 2012 6,288 10 View

What is the precise incidence of autoimmune diseases in the US and worldwide?

Some studies indicate that the incidence of autoimmunity as 5% and then there are other reference that suggest it is as high as 15%. This is big difference and we need to define it better. Any...

16 April 2012 9,546 5 View

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