Organic Chemistry

Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions,... | Contact experts in Organic Chemistry to get answers

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Questions related to Organic Chemistry

Which software/Website that can help me in IUPAC nomenclature and atom numbering ?

I'd like to know the correct numbering of atoms within large heterocyclic molecule, and the nomenclature of parts of it, so when I select a portion of the compound I can know what is the IUPAC...

05 January 2018 7,571 13 View

What is the reactivity of 2-aminoimidazole?

Can anyone say something about the reactivity of 2-aminoimidazole? I think this compound significantly differs in term of chemistry from other heterocyclic amines, e.g. 3-amino-1,2,4-triazole,...

01 January 2018 794 3 View

Does anyone have an easy technique on sample preparation for NOE experiment?

NOE experiments require de-gassing to get rid of dissolved paramagnetic oxygen. It is not easy to de-gass and seal the nmr tube. Is there any easy way to do it properly without using expensive...

01 January 2018 3,907 4 View

What are the interactions could happens in-between polyaniline and methacrylate groups ?

Most of research studies made a composite of methacrylate and polyaniline, but most of them just describes interaction is physical adhesion. But when examine the number of papers there and many...

01 January 2018 8,087 2 View

How can I clear neuromelanin from a tissue sample?

We are trying to do RNA FISH on a human midbrain sample and are having an issue with auto-fluorescence from the neuromelanin naturally present in the sample. Does anyone have a method to remove...

01 January 2018 4,610 0 View

What is the process of ion complex formation of molecules in organic solvent?

Hi, I have a question in forming ionic complex. I see some people making ionic complex of partially ionizable drug to increase lipophilicty and incorporate it into the lipid matrix. However, a...

01 January 2018 8,078 4 View

Which software/Website that can help me in IUPAC nomenclature and atom numbering ?

I'd like to know the correct numbering of atoms within large heterocyclic molecule, and the nomenclature of parts of it, so when I select a portion of the compound I can know what is the IUPAC...

01 January 2018 3,610 13 View

Will Silanols from Silical Gel of Flash Column Chromatgraphy (FCC) affect mesylation of diol?

Hello, I have done a mesylation reaction on some diol I made but I keep getting so many side products. I recently purified a new set of diols using FCC to try the mesylation reaction with MSCl...

01 January 2018 6,520 5 View

What is the significance of Rf value of organic compounds in medicinal chemistry ?

Rf values (TLC and HPLC) are used to identify the drug molecules. However this information can be of great value in medicinal chemistry and drug discovery. I think there's a great correction...

31 December 2017 9,124 11 View

How to reduce NO2 to NH2 without affect any other group in following reaction?

Hi, I have to reduce the NO2 group to NH2 group in the following reaction. Kindly suggest some good catalyst to reduce the NO2 to NH2 group without affecting any other position.

21 December 2017 8,394 51 View

The Raman stretching vibration around 514 and 913 cm-1 corresponding to what?

I did Raman spectrum of dimethyl carbonate ( (H3CO)2C=O ) and got two peaks at 514 and 913 cm-1. The molecule of dimethylcarbonate contains C=O group, CH3 group, OCH3 group and these groups have...

12 December 2017 5,872 4 View

What is the FT-IR frequency range for an active methylene group in an ethyl acetoacetate compound ?

I am looking for the frequency range for the active methylene groups between the ester and the carbonyl groups in an acetoacetate functionality.

12 December 2017 9,219 4 View

How do I know the configuration of the chiral molecule I made?

I synthesized a molecule which has two chiral centers. So, I got diastereomers which I am able to separate through column. How do I determine the configuration of these molecules?

12 December 2017 4,876 14 View

How to reduce NO2 to NH2 without affect any other group in following reaction?

Hi, I have to reduce the NO2 group to NH2 group in the following reaction. Kindly suggest some good catalyst to reduce the NO2 to NH2 group without affecting any other position.

12 December 2017 1,624 42 View

Can i use AlCl3 a catalyst for cyclization reaction?

Aim of my work is to synthesis of Molecule 2 (Fluoroquinolone) using diphenyl ether as catalyst. Even after several attempts the molecule 2 fails to form due to deactivation of para position by...

12 December 2017 2,414 14 View

What is the FT-IR frequency range for an active methylene group in an ethyl acetoacetate compound ?

I am looking for the frequency range for the active methylene groups between the ester and the carbonyl groups in an acetoacetate functionality.

12 December 2017 10,119 3 View

The Raman stretching vibration around 514 and 913 cm-1 corresponding to what?

I did Raman spectrum of dimethyl carbonate ( (H3CO)2C=O ) and got two peaks at 514 and 913 cm-1. The molecule of dimethylcarbonate contains C=O group, CH3 group, OCH3 group and these groups have...

11 December 2017 8,849 3 View

When the OLED carbene ligand deep blue ir dopant sublimates, fac and mer isomer are produced . How do I get fac isomer?

When the OLED carbene ligand deep blue ir dopant sublimates, fac and mer isomer are produced. I don't want mer isomer. How do I get fac isomer?

11 December 2017 9,538 1 View

What are the Optimized ESI-Mass parameter in order to achieve Maximum sensitivity?

1. Currently I am running the ESI-MS under these parameter & I just want to make sure that these parameters are accurate for proper & long time functioning of ESI-MS instrument. Right Now...

27 November 2017 3,737 4 View

Whether a tauc plot is suitable for organic molecules to find the band gap...?

A reviewer suggests that "The Tauc plot is only valid for semiconducting materials", and I did not have any idea about the conducting nature of my organic material since it is not my interest. I...

19 November 2017 6,310 6 View

P-aminobenzoic acid doesn't dissolve in HCl solution after cooling?

I met this problem when making diazonium salt from p-aminobenzoic acid. 0.02 mol of p-aminobenzoic acid (PABA) was added to the HCl solution ( 5 ml of concentrated HCl in 35 ml of water). The...

14 November 2017 3,261 5 View

Which type of photoisomerization process is likely to proceed for imine dyes with salicylaldehyde (ortho-OH benzaldehyde) group?

Whenever double bonds, such as C=N, C=C, N=N are presented, dyes may have photochromic properties and can be confirmed by light irradiation. By identifying another long-lived/reversible peak in UV...

11 November 2017 6,165 1 View

What are the Optimized ESI-Mass parameter in order to achieve Maximum sensitivity?

1. Currently I am running the ESI-MS under these parameter & I just want to make sure that these parameters are accurate for proper & long time functioning of ESI-MS instrument. Right Now...

11 November 2017 972 4 View

Does Vibrational Circular Dichroism (VCD) require the presence of a chromophore or a group with distinct IR absorption?

I have diterpene pyrones with 6 stereocenters. The molecules have a strong alpha pyrone chromophore as well as 2 carbonyls. However, at least 4 of them are far from those chromophores ? Would that...

11 November 2017 7,659 4 View

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