Organic Chemistry

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Questions related to Organic Chemistry

In the preparation of glycerol, the intermediate compound 2-chloropropan-1,3-diol is formed after addition of HOCl to allyl alcohol. How?

When HOCl is added to propene, the product is 1-chloro 2-propanol. However, when the same HOCl adds to allyl alcohol, the expected product is 3-chloropropan-1, 2-diol. But actually,...

10 October 2019 8,319 4 View

Any efficient procedure for the coupling at alpha position of the following compound???

I was previously using one of the strong base NaOH in order to convert it into sodium naphtholate (as my compound's physical appearance is in flakes form) then at the coupling stage with...

10 October 2019 9,190 3 View

How can i reduce the oxidising effect of nitrous acid (HNO2) on diazonium chloride??

Is there any effective method to reduce oxidation effect of nitrous acid (HNO2) as it is converting my diazo compound into tars while diazotizing it,affecting the results of my final...

01 October 2019 2,555 8 View

Can someone hint at anhydrous active methylene (sigma donor) nucleophiles (e.g. Malononitrile, but preferably more anhydrous)?

The idea is to use base to create an anhydrous strong nucleophile, which needs to be as anhydrous as possible. Also the nucleophile should act as a sigma donor and not pi. Any leads is much...

18 September 2019 8,631 4 View

Coordination of ketones to iron?

Hello everyone, I would like to know if someone have a reference or a possible explanation about if ketones (2-propanone or ethyl acetate) could coordinate to iron (metal or cation)? Since...

01 September 2019 4,525 3 View

Cubegen without scripting possible?

Cubegen operation possible in Gaussian-09 without scripting? If yes, how? Need suggestion please.

21 August 2019 2,271 3 View

What is the fate of NH2 and OH groups in chitosan when we use it as a reducing agent to produce metal nanoparticles?

It is said that NH2 and OH groups are involved in the reduction process of metal ions during nanoparticle synthesis. Do these groups get converted to some other groups (their oxidised forms) as a...

12 June 2019 256 2 View

TBMDS Protection of a Phenol going way over expected time?

Hi - first post here please let me know if there's a format I ought to follow. I'm running a TBMDS (TBS) protection of a phenol molecule that was previously purified by flash chromatography; no...

06 June 2019 7,330 5 View

Why is the yield of using the 2-fluoroboronic acid coupling with 4-methoxylisatin much lower than using 4-fluoroboroic acid?

I am synthesizing the compound 1 by using chan-lam reaction as the figure showing. However, the conversion yield of ortho fluoroboronic acid (less than 20% on LC/MS) is much lower than the para...

06 June 2019 6,742 10 View

Why is the yield of using the 2-fluoroboronic acid coupling with 4-methoxylisatin much lower than using 4-fluoroboroic acid?

I am synthesizing the compound 1 by using chan-lam reaction as the figure showing. However, the conversion yield of ortho fluoroboronic acid (less than 20% on LC/MS) is much lower than the para...

02 June 2019 3,165 9 View

What is the thermal stability of aldehyde groups on the surface of glass?

I am attempting an experiment that involves high temperature (65°C) treatment of glass slides pre-coated with aldehyde groups. Upon this process, hydrophobic property of the glass slide (Contact...

05 May 2019 7,451 3 View

Are there any bioisosteres of triple bond?

Are there any bioisosteric replacements of triple bond (alkyne) which were employed for lead optimization or scaffold hopping? Thanks.

24 April 2019 2,750 4 View

How to convert anhydrides into acid hydrazide?

Dear colleagues, kindly share me your experience to convert phthalic anhydride into phthalic hydrazide Thanks in advance

24 April 2019 8,792 11 View

Why do we observe a heptet for 13C NMR absorption peak of CD3OD?

Heptet means 6 neighbor hydrogens but base on CD3OD structure, it cannot be 6

20 April 2019 7,116 3 View

Are there any bioisosteres of triple bond?

Are there any bioisosteric replacements of triple bond (alkyne) which were employed for lead optimization or scaffold hopping? Thanks.

04 April 2019 2,831 5 View

Can a pyridine ring bind to APTES silanized glass using succinic anhydride?

I am looking for a stable bond between pyridine ring and Glass surface which can work in physiological aqueous conditions.

04 April 2019 3,492 1 View

How to prevent secondary amine formation in nitrile reduction?

I am reducing the -CN group（with an α-NHBoc） to a primary amine with Hydrogen & Pd/C in MeOH. However after 24hs' reaction, it gives largely "dimmer-like" byproduct, namely secondary amine....

04 April 2019 2,687 8 View

Does anyone knows if Trispentafluoroborane air sensitive? I mean to what extent it is air sensitive? Very sensitive or mildly sensitive?

Dear All, I know that Trispentafluoroborane is air sensitive but need to know how much it is sensitive. When I run reactions with this catalyst do i need to pay very carefully attention for...

15 March 2019 9,477 5 View

How do I remove sodium methoxide from solution after reaction?

I have deprotected acetyl group from protected galactose in a glycopeptide compound using NaOMe in MeOH, I want to inject this mixture to LCMS, is it OK to inject it directly without removing first?

13 March 2019 9,479 2 View

Does anyone knows if Trispentafluoroborane air sensitive? I mean to what extent it is air sensitive? Very sensitive or mildly sensitive?

Dear All, I know that Trispentafluoroborane is air sensitive but need to know how much it is sensitive. When I run reactions with this catalyst do i need to pay very carefully attention for...

03 March 2019 7,547 6 View

On which basis we can select column in Column chromatography?

I need help regarding column chromatography. Your help in this regard is really helpful for me. On which parameters we can select the length and width of column. What size of silica is good for...

14 February 2019 601 8 View

On which basis we can select column in Column chromatography?

I need help regarding column chromatography. Your help in this regard is really helpful for me. On which parameters we can select the length and width of column. What size of silica is good for...

02 February 2019 6,201 9 View

How to analyze and report GC-FID results (FAME) from data processing software?

Hi, I ran analysis on the concentration of Fatty Acids Methyl Ester (FAME) of freeze-dried fish sample using Shimadzu GC2010Plus and its companion software GC Solution. I first plotted a 4...

02 February 2019 887 4 View

How to convert heterogeneous sodium carboxylate form to a free carboxylic form?

I am preparing a heterogeneous adsorbent for heavy metal removal. the main active group was the carboxylic group. during preparation, the catalyst was treated with aqueous sodium hydroxide for a...

09 January 2019 6,904 9 View

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