Because the endothelial glycocalyx may be attenuated and or lost due to multiple metabolic toxicities in the intersection between Type 2 Diabetes and Met S in COVID-19 and the endothelial glycocalyx is known to harbor Xanthine Oxidase could Uric acid regionally at the blood-gas barrier be elevated and contribute to Redox stress.
SEE PAPER:
Hayden MR1, Tyagi SC. Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond). 2004 Oct 19;1(1):10.
This question and discussion is open to any and all and please comment on this
regarding your thoughts and ideas and further references.
Melvin Hayden, MD
Missouri USA
Lymphopenia and lactic acidosis predict COVID-19 severity and prognosis
Critical cases of COVID-19 may be associated with tissue hypoxia and lactic acidosis. Lactic acidosis in association with COVID-19 can also be associated with secondary infection and bacterial sepsis and multiorgan failure. Lymphopenia indicates the severity of the illness and is a prognostic factor in patients with COVID-19, and lactic acidosis is one of the cause of lymphopenia (2)
1. Article Lactic acidosis
2. Article Lymphopenia predicts disease severity of COVID-19: a descrip...
