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Questions related from D'Souza Joseph
I want to do a pharmacokinetic study for oral administration of a compound. I calculated conc. vs time. I'm using R program with PK package for non compartmental analysis. With the batch design, I...
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Kindly some one help me to calculate the Peff value from the small intestinal perfusion study. We are collecting samples for the regular interval of time and analyzing the concentration (Cout). So...
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I want to determine the Effective permeability (Peff) for the bioactive through insitu small intestinal perfusion study. I read the articles related to this method. Researchers are using this...
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I'm preparing tocopherol emulsion. After that, I want to analyze the tocopherol present in that emulsion through HPLC. I take the emulsion (1 ml) with 5ml hexane:DCM mixture. Then centrifuge,...
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I'm preparing emulsions with protein as stabilizer. Many carried out emulsion stability and activity by adding 1% SDS (sodium deodecysulfate) and checking the abs immediately and after 10 min of...
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Researchers preparing emulsion with some surfactant (like Tween, Protein) and finally adding Chitosan. Why can't they use the chitosan as surfactant and develop the emulsion?
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In the everted gut sac method or in situ intestinal perfusion study, drug is directly injected into the intestine without considering the passage through mouth and stomach. Why researchers are...
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