11 Questions 28 Answers 0 Followers
Questions related from D'Souza Joseph
I want to find the oral bioavailability for spray dried encapsulated bioactive compound. I used protein as wall material. My query is how to feed my powders into rat by intragastric...
14 August 2015 6,098 13 View
I prepared O/W macroemulsion and studied for one month storage at three different conditions (4, 25 and 40 deg C). At the end (on 30 th day), I found slight creamy layer and checked for droplet...
26 June 2015 1,765 7 View
I want to do a pharmacokinetic study for oral administration of a compound. I calculated conc. vs time. I'm using R program with PK package for non compartmental analysis. With the batch design, I...
10 June 2015 342 5 View
I want to find the bio-availability of vitamin E from the emulsion in rats. My doubt is, rats are already having vitamin E from the diet. How could I keep the control and find the increase in...
05 May 2015 274 3 View
Kindly some one help me to calculate the Peff value from the small intestinal perfusion study. We are collecting samples for the regular interval of time and analyzing the concentration (Cout). So...
24 March 2015 7,348 3 View
I want to determine the Effective permeability (Peff) for the bioactive through insitu small intestinal perfusion study. I read the articles related to this method. Researchers are using this...
19 February 2015 1,995 2 View
I'm preparing tocopherol emulsion. After that, I want to analyze the tocopherol present in that emulsion through HPLC. I take the emulsion (1 ml) with 5ml hexane:DCM mixture. Then centrifuge,...
03 February 2015 1,227 5 View
I'm preparing emulsions with protein as stabilizer. Many carried out emulsion stability and activity by adding 1% SDS (sodium deodecysulfate) and checking the abs immediately and after 10 min of...
31 December 2014 147 11 View
Researchers preparing emulsion with some surfactant (like Tween, Protein) and finally adding Chitosan. Why can't they use the chitosan as surfactant and develop the emulsion?
10 November 2014 5,144 10 View
In the everted gut sac method or in situ intestinal perfusion study, drug is directly injected into the intestine without considering the passage through mouth and stomach. Why researchers are...
31 July 2014 1,280 2 View
I want to calculate the concentration of vitamin in blood plasma. I followed a procedure from an article. taken 1 ml of plasma, added 5 ml of hexane (to extract the compound), centrifuged. two...
17 July 2014 6,989 2 View
