In the everted gut sac method or in situ intestinal perfusion study, drug is directly injected into the intestine without considering the passage through mouth and stomach.
Why researchers are not considering the passage through mouth and stomach?
Thanks for your reply Fakhrul.. In those links they given the procedure for doing the intestinal release studies. They never uttered why they moved straight to the small intestine, without stomach stage.
in oral cavity the dosage form passage time is negligible, and it reach the stomach in 1 minute or so. now as you have mentioned drug may released in stomach before reaching intestine, to quantify it normally people carry out the release study for 1-2 hour in 0.1M HCL, further stomach condition may be simulated by adding other enzymes. but these are in-vitro methods. then the dosage form is added to another set up with basic buffer, here the sac can be applied. when we are directly moving to intestinal release the preassumption is that the dosage form is almost inert to the stomach conditions, eg enteric coating. your query is really interesting, hope we will see some works taking the whole excised stomach for release study..
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