19 September 2014 1 368 Report

As a byproduct of my synthesis I might have a N,O Boc protected Thr, on resin, which for the next steps needs to be kept capped.

The resin is subjected to a 6h treatment with 70% Pip in DMF, to free the phenolic OH from the Boc which surely reacted in presence of DMAP, to afford the corresponding Phenyl-Boc mixed carbonate-ester. Would this treatment even cause the unwanted deprotection of the above mentioned alkyl OH on the threonine, from the Boc? thanks to everybody

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