Majority (About 80%) of sufferer of autoimmune diseases are women. These gender differences may be due to effects of hormones or fetal cell microchimerism. Is there any thing else that might cause these gender differences?
Yes. Please read our reviews for more details.
https://www.ncbi.nlm.nih.gov/pubmed/21902548
Article Modulation of autoimmune rheumatic diseases by oestrogen and...
Gender is an expression of chromosome X:
"Gender plays a major role in susceptibility to SLE, with a 9 : 1 female-to.male tatio during reproductive years, suggesting a hormonal contribution to immune dysregulation. ...Exposure to female hormones appears to confer risk for mild to moderate flares in SLE. ...men with Klinefelter syndrome (XXY) and women with triple X syndrome habe a 14-fold and 2.5 fold increase in SLE risk. ...Indeed, the chromosome encodes several genes considered relevant to SLE pathogenesis (CD40 ligand, IRAK1, FOXP3, TLR7, and MECP2), that could be overexpressed in females because of incomplete epigenetic X inanctivation."
[Gupta, S, Kaplan, M.J.: Pathogenesis of systemic lupus erythematosus. In: Rheumatology, Ed. Hochberg, M.C. et al. Elsevier Philadelphia 2019: 1154.
It is not only the role of sexual hormones, must be other immunologic or genetic factors associated
Please take a look at the following RG link.
Article The female-biased factor VGLL3 drives cutaneous and systemic...
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