Dear All,
We had prepared Nanoparticles and we plan to compress them into tablets for oral route delivery. This is to increase the Bioavailability of the drug.
There are many articles that state that Nanoparticles can be compressed into tablets and provided via oral route.
But, please can you let me know whether these Nanoparticles will aggregate when compressed to tablets of will they stay as nanoparticles when the tablet disintegrates in the GI fluid.
We will cross check this with SEM of the disintegrated tablet but want to know whether it will?
Also let me know any options like addition of excipients in the tablet that allow the nanoparticles to stay seperate after the tablet disintegrate in the GI fluid.
We also use Poloxamer in nanoparticles prepearation to avoid this problem.
Your suggestions will help me a lot.
Thanks in advance
It is a question of thermodynamic properties of the system. Systems usually tend to minimize internal energy. If the minimum energy is in the form of nanoparticles, this is the favorable state of the system. It strongly depends on the nanopartciles type and addition of protective agents / surfactants – substances that prevent physical contact between nanoparticles. We make posysaccharide nanoparticles which are formed by selfassembly. So the minimal energy in the solution is when they are in the form of nanoparticles. After resuspension in water they need about 15 minutes to recreate initial size distribution (like micelles). If the minimum energy is in the bulk form (less surface - lower surface energy) materials will never form nanoparticles spontaneously. Addition of surfactants may decrease surface tension - energy and promote suspension, decrease the speed of aggregation. We make HAP nanoparticles, when compressed without protective surfactant they will never resuspend in water. The same story we observe with silver nanoparticles.
The answer will very much depend on tablet composition. In principle chance of aggregation is high. When there is direct contact of the particles interparticle bonds may form like in case of silica. Second, will the particles have repulsive interactions when they get into contact with biofluid?
@Titus: The nanoparticles did not show any aggregation in the acidic pH. Hence if we compress the nanoparticles into tablets once if it reaches the stomach will it disintegrate and converts to nanoparticles without any aggregation?
from another question of you I suspect that the question is about chitosan particles. I do not know but would suspect that interparticle bounds can be formed unless they are protected from doing so. I would think that the related problem might be studied separately by comparing dispersion state of the particles before tablet formation and after redispersion of the tablets. Aging the tablets likely have an effect on interparticle bond formation if occur.
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