Why would a CDH6 mAb ADC conjugated to a novel membrane permeable topoisomerase have safety issues?

13 December 2021 0 9K Report

A similar ADC HKT288 that used a DM4 payload with anti-CDH6 monoclonal was discontinued over inflammatory and neurological adverse events. Would the adverse events be tied to targeting CDH6 or to payload toxicities?

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