Dear Vladimir,

Autoimmune Hemolytic Anemia (AIHA) is a blood disease in which a person produces substances that cause their own body to destroy red blood cells, resulting in anemia.

Causes

Hemolytic anemia may be caused by any one or more of several kinds of disorders. For example, contributing factors may include:

An autoimmune response in which the patient’s own immune system destroys the patient’s red blood cells. The disorder is more common among people who already have an autoimmune disorder such as lupus.

The taking of certain types of medication by certain people. Among such medications are penicillin, quinine, methyldopa, and sulfonamides.

Inherited enzyme deficiencies inside red blood cells that may cause the cells to become fragile and subject to destruction. Most commonly, low levels of the enzymes pyruvate kinase or glucose-6-phosphate dehydrogenase are the culprits.

Hemoglobin disorders such as sickle cell anemia or one of the thalassemias (blood disorders that affect the cells ability to produce hemoglobin).

Abnormalities of the cell membrane that cause the red blood cells to take on a shape other than the normal disc-shape. Such red blood cells may show up as spheres or ellipses or cup-like.

Since some of the disease causes is attributed to inherent enzymes deficiency or diseases caused by gene defects or etc. doctors avoid blood transfusion from relatives in order to eliminate any risk that might come from inheriting causes.

http://rarediseases.org/rare-diseases/anemia-hemolytic-acquired-autoimmune/

Hoping this will be helpful,

Rafik

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