effect of surfactant like tween-80 on the native flourescence of some drugs???
Dear Walid,
This phenomenon is related to the fact that polysorbate (Tween) 80 and other surfactants may attenuate the incorporation of anionic compounds (drugs) into the membranes. It is suggested that polysorbate 80 modifies some of membranes and intracellular physiological parameters without affecting the cell viability, thus affecting the penetration or permeation of some drugs which leads to changes in their native flourescence .
For more details on this phenomenon, please use the following links:
http://www.ncbi.nlm.nih.gov/pubmed/15147788
http://www.ncbi.nlm.nih.gov/pubmed/15858848
http://www.sciencedirect.com/science/article/pii/S2211383513000774
Hoping this will be helpful,
Rafik
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