Mauro Luisetto, Thanks for the article. It really helped me to understand my query.

Bishnu Neupane neurodegenerative diseases like Parkinson, Alzheimer, ALS, HD etc are characterized by proteinaceous aggregates. Therefore, insoluble small molecules are strategically targeted against them to inhibit protein aggregation, thus thought to be cure for neurodegenerative protein misfolding diseases.

Nida Fatima thank you very much for direct and clear answer.