IL-6 (considered as prime culprit) and other cytokines (TNF-alpha, IFN-gamma, IL-1, IL-2 etc) are associated with COVID-19 related cytokine storm and further morbidity and mortality . The current research is mainly focusing on costly monoclonal antibodies like Tocilizumab, siltuximab and sarilumab (IL-6 inhibitors) . These are injectable drugs and are also associated with troublesome adverse effects.
On the other hand existing age old drugs like tetracyclines have multifaceted anticytokine actions (they inhibit IL-6, TNF-alpha, IFN-gamma and other cytokines) and they also offer other benefits in terms of cost, orally available, and their safety profile is well established. Efforts should be made to reposition these drugs particularly in developing countries to save the money and time . Drug
re- purposing could be a very useful approach in this aspect.
Kindly give your input
Here you have a link of what is discussed. There are several laboratories that try to found the vaccin for Covid-19 now. They have tried all kinds of medications during the active phase of the pandemi. Still, we have in Finland soon 300 fatalities. https://theconversation.com/could-bcg-a-100-year-old-vaccine-for-tuberculosis-protect-against-coronavirus-138006
I think this link would be helpful:https://www.researchgate.net/deref/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F32267566
Interesting thing on similar concept
Interesting thing to follow.
https://medicaldialogues.in/medicine/news/doxycycline-and-ivermectin-combo-may-be-new-effective-covid-19-treatment-65868
I along with my colleagues, have written a critical review on a similar promising drug . It is in the advanced stages and likely to be published soon. Good to see that this idea is going in the right direction. Hope to see some good research in this area.
SARS-CoV-2. COVID-19. - Cytokine Storm. Proinflammatory cytokines. Cholinergic anti-inflammatory pathway
https://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway
(see: https://www.researchgate.net/post/What_is_a_new_idea_How_are_new_ideas_born_in_science_art_and_politics )
SARS-CoV-2. COVID-19. - Cytokine Storm. Proinflammatory cytokines. Cholinergic anti-inflammatory pathway https://en.wikipedia.org/wiki/Cytokine_release_syndrome
https://www.researchgate.net/profile/PF_Zabrodskii/research
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Article [Effect of armin on nonspecific resistance factors of the bo...
Article Variation in antiinfectious nonspecific resistance of the or...
Article P.F. Zabrodskii. Effect of acetylcholine on mortality of mic...
[ Article [The effect of anabasine on mortality and concentration of p...
Article P.F. Zabrodskii, M.S. Gromov, V.V. Maslyakov. The combined e...
Article Effect of α7n-Acetylcholine Receptor Activation and Antibodi...
Article The Influence of Cholinergic and Adrenergic Drugs on Mortali...
https://www.actascientific.com/ASPS/pdf/ASPS-03-0415.pdf
Article Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Ago...
Article https://link.springer.com/article/10.1007/s10517-017-3886-8
Article Role of β2-Adrenoreceptors in Adrenergic Anti-Inflammatory M...
Article The Combined Effect of STAT3 and NF-Κb Inhibitors (The Last ...
Article Prospective Methods of Sepsis Treatment by Activation of the...
Article The Mechanisms of the Cholinergic Anti-inflammatory Pathway
https://biomedgrid.com/fulltext/volume6/the-adrenergic-mechanism-in-the-implementation-of-the-cholinergic-anti-inflammatory-pathway.000990.php
P.F. Zabrodskii
This is written with the similar idea
https://www.tandfonline.com/doi/full/10.1080/14787210.2020.1782190
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