Harmanjit Singh

12 Questions 56 Answers 0 Followers

Questions related from Harmanjit Singh

Do we need further research on HCQ and Azithromycin combination ?

Both HCQ and Azithromycin are known cardiotoxic drugs. Provided that COVID-19 infection also leads to myocardial injury and may present with variety of cardiovascular conditions. Will this...

16 July 2020 5,151 8 View

What is your opinion on potential role of chemically modified tetracyclines in severe COVID-19 and its complications?

Chemically modified tetracyclines (CMTs) are non antibiotic derivatives of tetracycline having very potent immunomodulatory effects. They inhibit pro-inflammatory cytokine and mediators well...

16 July 2020 6,864 0 View

Can Minocycline be a better option to combine with HCQS in hospitalized patients with COVID-19?

Minocycline is also a cheaper and older drug with broad spectrum antimicrobial profile. It can offer some advantages over azithromycin which is being combined with HCQS in COVID-19 patients: It...

11 June 2020 5,796 6 View

What is your opinion on your ICMR expanded recommendations on use of Hydroxychloroquine for prophylaxis for COVID among health care professionals ?

These revised guidelines have now recommended the prophylactic use of HCQ for all asymptomatic healthcare providers (HCP) involved in containment and treatment of COVID19 and asymptomatic...

26 May 2020 9,687 26 View

Why researchers are not focusing on existing Anticytokine drugs rather than costly molecules for the treatment of COVID-19 ?

IL-6 (considered as prime culprit) and other cytokines (TNF-alpha, IFN-gamma, IL-1, IL-2 etc) are associated with COVID-19 related cytokine storm and further morbidity and mortality . The current...

16 May 2020 3,576 8 View

What is your opinion about SOLIDARITY trial being run by the WHO in international collaboration for COVID -19?

They have selected drugs for which many studies are already available and most of the studies have shown discouraging results. They have mentioned that they are selecting these drugs based on...

13 May 2020 2,407 7 View

Why convalescent plasma (CP)should be given in patients mild COVID -19 infection?

Considering the difficulties linked with obtaining donors, availability of adequate titres of neutralizing antibibodies from each donor and controversial results of the available studies, does it...

06 May 2020 1,863 11 View

What is your opinion on role of BCG vaccine in COVID-19?

BCG vaccine is being seen as a new hope for COVID-19 patients. It can make our immune system to recognize and respond to a variety of infections, including viruses, bacteria and parasites etc...

28 April 2020 7,857 30 View

Isn't it important to obtain the written informed consent of COVID-19 patients or their relatives while offering them unproven off-label drugs?

This is a very controversial issue. Patients who are likely to be prescribed off-label unproven drugs for COVID-19 management e.g. HCQS and Azithromycin , may also develop serious adverse effects...

21 April 2020 2,424 19 View

What is your opinion on use of Hydroxychloroquine (HCQ) for prophylaxis among health care providers and close contacts exposed to COVID-19 patients?

There is no comprehensive evidence for use of HCQ for prophylaxis of COVID-19. Few studies with small sample and that too with flaws in research methodology are available. Most of the published...

15 April 2020 7,356 21 View

Can someone provide a list of PubMed indexed Medical journals specifically publishing undergraduate research papers ?

I want to know about biomedical journals publishing undergraduate research articles.

03 February 2020 5,586 3 View

How important is Bempedoic acid in reducing LDL-C in patients who are not responding well to maximal doses of statins?

Bempedoic acid inhibits ATP citrate lyase (ACL), an enzyme which converts Citrate to Acetyl CoA . After this step, the pathway is same i.e. Acetyl CoA to HMG CoA and mevalonate (targeted by...

23 January 2020 9,777 3 View