Why male species are more preferred over female for depression or other neurological preclinical studies ?

01 January 1970 1 9K Report

What should be a valid reason to use male mice for depression studies and excluding female mice.

Hi, there are lots of papers implying the role of sex hormones on mood regulation, and perceptual and cognitive performance. These effects would be more pronounced if the hormones also change significantly in a periodic manner like female cyclic alterations. So, when you select male samples you are accepting the role of sexual hormones but you are controlling for the fluctuations (which is another layer of variation). Rashmi Patil

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