The rate at which substances are filtered is very high. High turnover rate. GFR is high.The osmolality of the most region is also high due to dissolved substances making it hostile to microbial growth.
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents—the glomerular endothelial cell, the basement membrane and visceral epithelial cell