The deficiencies in the urea cycle causes
fluctuations in the levels of these amino acids in patients accompanying serious diseases known as urea
cycle disorders, such as citrullinemia, argininemia, and
argininosuccinic aciduria. In addition to these diseases, plasma citrulline levels have been proposed as
an effective biomarker of bowel activity and intestina function in various pathologies .These findings
indicate that the rapid determination of L-citrulline and
L-arginine is a beneficial technique not only for scientific research, but also for medical applications.
Kindly read this paper for your reference-------------------_----------------------+
Rapid enzymatic assays for L-citrulline and L-arginine based on
the platform of pyrophosphate detection
Masafumi Kameya a, b and Yasuhisa Asano a, b,
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