Hi Everyone,
Entecavir 0.5 mg is usually given for patients with chronic hepatitis B to keep the virus under control and as well Vaccine is available for restricting the virus. If Entecavir 0.5 mg can keep the virus under control, why there is no drug discovered to completely eradicate the virus from the system. well viruses are obligate intra-cellular parasites but for some viruses there are drugs that can completely eradicate it.
The HBsAg clearance rate remains low with any antiviral available in the current market. The main reason we start the antiviral treatment in those with Chronic Hepatitis B is to alleviate liver inflammation or necrosis and to reduce the incidences of liver cirrhosis, and hepatocellular carcinoma. Antiviral drugs can not directly act on cccDNA, which makes it difficult to eradicate.
hlo sir, this can happen because Hepatitis B is included in the dsDNA virus. Structurally, the virus also does not have cell walls Like a bacteria, fungi so that treatment efforts using drugs are ineffective. Vaccines can be done for this. In addition, materials that have immunomodulatory properties also have the potential to increase the immune system against Hepatitis B.
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