Guillain-Barré Syndrome (GBS) is a rare autoimmune disorder that causes muscle weakness and paralysis.
I am worried about the loss of life happening in the ongoing Pune GBS outbreak, Arvind Sharma, as much as you.
The recent surge in Guillain-Barré Syndrome (GBS) cases in India, particularly in Pune, Maharashtra. Maharashtra has reported 225 Guillain-Barré Syndrome (GBS) cases so far (22 March 2025). The outbreak has resulted in 12 fatalities according to state health authorities. Cases are reported from multiple areas, including Pune Municipal Corporation locality, Pimpri Chinchwad Municipal Corporation, and Pune Rural.
Likely cause:
Water contamination. The National Institute of Virology (NIV) in Pune has found Campylobacter jejuni in stool samples of patients with GBS, suggesting a possible link between the bacteria and the outbreak. Earlier, me and my coworkers reported the presence of anti-C. jejuni antibodies in approximately 1/3rd of patients with GBS. Heed here: Article Antecedent infections in Guillain-Barré syndrome patients fr...
(for the larger public interest, I attached the 'Accepted Article' version of the published paywalled article.)
Steps from authorities:
The World Health Organization (WHO) has mobilized support for local health authorities to manage the outbreak effectively. The Maharashtra state government has intensified surveillance efforts and is coordinating with hospitals to ensure adequate treatment for affected patients.
Having said that, both local and national governments need to conduct investigation on the long-rooted GBS susceptibility of the Pune inhabitants. We published evidence of a multitude of risk factors including genetic polymorphisms. Heed here: Article Variations within Toll‐like receptor (TLR) and TLR signallin...
#GBsyndrome #NIV #Campylobacter #WHO
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