i am doing the surface modification of gold nanorods by using chiral molecules like Cysteine, glutathione etc. I simply mixed the gold nanorods with these molecules with strong agitation at different pH. but the gold nanorods aggregate/precipitates in solution rather than staying intact. can anyone help me in this regard that how to solve this problem?
You are watching an interesting phenomenon. Amino acids from proteins have l - absolute configuration. The rods, apparently, are also twisted in the l-configuration of the helix. Try using the d-configuration of amino acids. Then your rods will be combined with amino acids.
I am using both the forms D and L of these molecules but with molecules i am getting the same results , precipitation of nanorods
If it doesn’t hurt you, add a little alkyl mercaptan. Their solubility and adsorption capacity on gold nanoparticles depends on the chain length.
Shpuld i add alkyl merceptan in solution of gold nanorods and amino acids ?
Yes, you can add alkyl mercaptan to the dispersed system of amino acids and nanorods. Alkyl mercaptan has weak acidic properties and reacts with amino groups of amino acids at a certain pH.
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