I asked my professor this question and she told me that the reason is not known till now. Why is that?
Dear Sherouk,
Do you know why you live? Do you know the mission of your life you have to complete before you pass away. There are certain things we do not know in order for researchers to have something to do. You can consult the authors here on RG:
Article Aging of the hematopoietic system
Article Development of the Hematopoietic System and Disorders of Hem...
Dear Béatrice,
Thank you so much for your answer. Research is all about asking yourself questions, and I'm just trying to think out loud here. What actually made me not able to let go of this question is the age spectrum itself; it's not the age during which the body experience a stage of physiological changes, not the age of puberty for example, not even 40! This makes it much more questionable.
Then we have something exciting to look forward to in all ages:)
My personal explanation, which is not based on any experimental data, the function of the long bones after the age of 3 years old requires them to be strong enough to carry the body weight as the individual starting doing a lot of weight bearing activities. For that reason the red bone morrow changed to yellow one and the bones getting harder and harder to start their main function as weight bearing organs. This would leave the Haematopoiesis confined to the other less strong central bones like the sternum, ribs and the vertebrae, to take the sole role of the red bone marrow. So it is a matter of evolutionary process of changing the functions of the body organs. Similar to the spleen for example in patient with extensive idiopathic myelofibrosis, the spleen will re-gain its function as a haematopoitic organ during the intra-utrine period, in order to compensate to the loss of the Bone Marrow function due to fibrosis.
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