Why did I not inhibit NLRP3 inflammasome activation by treating cells with itaconate?

05 September 2022 0 4K Report

I added 10mM or 20mM itaconic acid solution (PH7.0) into BMDM cells for 12h and then added LPS and ATP to induce the activation of NLRP3 inflammasome, but found that itaconate could not inhibit the activation of NLRP3 inflammasome

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