Proteins are a long chain of amino acids. In protein amino acids are bonded to each other by a peptide bond. Researchers trying to find the protein structure. Can an amino acid interaction network in a protein help us to find the protein structure?
I believe this method is being used now to help predict protein structures. I think the idea is that pairs of residues that co-evolve when comparing homologues (such as a basic residue and an acidic residue in one homologue but the opposite in another homologue) indicate that the two residues are bonding with each other.
It may give you clues. (The protein interactions could involve more proteins, could there be more interactions in between proteins?)
Sure. Side-chain interactions deduced from co-evolution statistics are used to improve ab-initio structure prediction.
Obviously. To identify the structure of a protein, study of the amino acids and their interactions is required.
Such networks, which are undirected by nature, helps to predict the structure of a protein. Additionally, the network perspective on biomolecules enables the efficient characterization of each individual amino acid within the network that includes protein–protein interfaces, catalytic residues, and allosteric regulation
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The function of proteins is often embodied in their interactions with other proteins and/or nucleic acids. The amino acid residues of the interaction sites can provide some auxiliary information for the prediction of protein structure.
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