Why all the amino acids that are ribosomically incorporated into proteins exhibits L-configuration not D-configuration?
I think that L - amino acids are slightly more stable.
Also amino acids from the solar system, metorites etc, are all L amino acids so maybe thats why all amino acids on earth are L-.
Hi Hirakjyoti,
My immediate guess is since amino acids are incorporated into the proteins in the L-form during the translation, it follows that they are also metabolized and biochemically processed in the L form. It is possible that the translation process dictates the L-stereoisomer amino acid to be the isomer which evolved and functional in the human body, involved in metabolic processes.
Best,
Hediye.
The real answer is that there is not good explanation to this question. Proteins are synthesized in the ribosomes.However, there are
some naturally occurring peptides with the D cofiguration.
Have a look to these references, please:
Thesis Through the mirror: Translation with D-amino acids
Article MALDI TOF/TOF-Based Approach for the Identification of d- Am...
The first explains your question and the second enlights a way do identify d-aminoacids.
Hope it helps.
"Evolution" is a generalization in this context, but is the most likely reason. One form prevailed. The mechanism of the process is what is studied and of interest. Look to bio-cosmology data for more info.
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