Greetings respected experts!
I am beginner in nanotechnology.I want to ask for in vivo research, using micronutrient metal e.g iron , Zn will be safe and good or other metals e.g Silica,silver, gold?
Thanks
Actually, I may not understand well this question. However, for in vivo studies, titanium dioxide nanoparticles are very good and non-toxic. But they are not acting as micronutrients. Best wishes
Hi, all the nano-particles for metals that in human body in origin. Therefor in vivo research, using metal e.g iron , Zn will be safe and good and other metals e.g Silica,silver, gold. But the best metals are silver and gold.
KINDS
The particular toxicity of silver NPs at a concentration of 15 mg / l was detected during the 48 hour incubation of spermatogenial cells of 6 day old mice.
Studies on the toxicity of cadmium, chromium, copper, nickel and zinc in aquatic daphnia culture (Daphnia magna) have shown that copper and zinc exhibit similar toxicity, which is enhanced at low pH values.
The manifestation of the toxic properties of other metals also depended on the pH of the medium. The effect of different concentrations of suspensions of NPs and zinc ions on aquatic cultures of daphnia and bacteria revealed lethal concentrations - 8.4, 3.1 and 6.5 mg / l for daphnia and 2.0, 1.5 and 1.4 mg / l for bacteria, respectively.
you can get nanocomposite of iron oxide ,gold etc. for in vivo study too.
Sumairan Bibi Magnetic nanoparticles such as magnetite are biocompatible. You can also try with gold and silver. In any case, you have to check first the cytotoxicity in cells. For more details:
Article Exploring Factors for the Design of Nanoparticles as Drug De...
All of the metal nanoparticles are non toxic to in vivo study until to take the high dosage. however the silver and gold are best choice for in vivo study with out toxicity for test animal.
Dear Sumairan.
Based on my expertise, there are many considerations that must be taken into account, regarding the use of nanoparticles for in vivo applications.
First of all, the core: I got nice results with gold, Ag-Au-Se, Fe3O4 and MnFe2O4. I had some problems with other XFe2O4 Nps (X=other metal).
However, for in vivo applications, the capping of the NPs is a crucial step (due to the potential toxicity and the stability in biological media as well as the final hydrodynamic diameter). I have always used as capping agent a PEGylated ligand. Avoid for example CTAB, which is quite toxic or positive charges in the outermost layer. As I mentioned previously, the hydrodynamic diameter is really important, since it determine the interaction between the NPs and the mononuclear phagocyte system (MPS). In thi sense, an immune response to NP will kill the animal.
I hope this comment helps you.
based on the my expertise silver and gold metal nanoparticles are best to use biomedical field.
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