What are overall assumptions for comparing two enzymes of the same class consisting of more or less different amino acids?

I do research on genetic code and aminoacyl-tRNA-synthetase (aaRS) evolution. An aaRS consists eihter of 18, 19 or 20 amino acids. Are there biological rules or findings that allow the assumption...

01 February 2019 929 8 View

Is there a similar approach on genetic code evolution?

Is there anything similar to a simulation that starts with a random genetic code and some genes that are translated into aaRS proteins which change the genetic code because the new aaRS aren't the...

31 December 2018 6,599 1 View

Does a flexizyme or sth. similar exist that can charge a tRNA with two different amino acids?

Is there any aaRS like construct that charges either... ...one tRNA with one out of two amino acids or ...two tRNAs with one amino acid each but not the same amino acid. Further more there is...

10 November 2018 5,994 0 View

How long does an Aminoacyl-tRNA-Synthetase live? How often is it reproduced?

For my current project I do a lot of research about aaRS but didn't find answers to these questions yet. I am happy about any information about the lifecycle of these enzymes.

10 November 2018 5,065 2 View

Ribozym, flexizym, mRNA, tRNA. What is missing for protein biosynthesis?

Protein biosynthesis in an RNA world could have had the following components: ribozymes instead of ribosomes, flexizymes instead of aminoacyl-tRNA-synthetases, mRNAs, tRNAs, other kinds of RNAs....

01 January 1970 4,779 1 View

Which research approaches consider the influence of protein biosynthesis products on genetic code evolution?

I've read a lot of research but didn't really find theories that include the influence of the produced proteins on the evolution of the process in general and the genetic code in particular. I'd...

01 January 1970 6,338 2 View

error in running a model in Abaqus

Excessive rotation of nodes in node set ErrNodeExcessRotation-Step1

17 August 2021 0 0 View

error in modelling model in Abaqus

Excessive rotation of nodes in node set ErrNodeExcessRotation-Step1

17 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MD MOE RMSD

How to calculate the RMSD values for a MD simulation using MOE?

07 August 2021 0 0 View

MGL tools

20 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

fatal error

When I tried to energy minimization my system, I got fatal error as below. Fatal error: Atomtype opls_116 not found Although I've already added this line: ; include water #include "oplsaa.ff/spc.itp" to [molecultype] directive in my topology.

16 June 2021 0 0 View

i have some problem with chtMultiRegionSimpleFoam

--> FOAM FATAL ERROR: Maximum number of iterations exceeded From function Foam::scalar Foam::species::thermo::T(Foam::scalar, Foam::scalar, Foam::scalar, Foam::scalar (Foam::species::thermo::*)(Foam::scalar, Foam::scalar) const, Foam::scalar (Foam::species::thermo::*)(Foam::scalar, Foam::scalar) const, Foam::scalar (Foam::species::thermo::*)(Foam::scalar) const) const [with Thermo = Foam::hConstThermo >; Type = Foam::sensibleEnthalpy; Foam::scalar = double; Foam::species::thermo = Foam::species::thermo >, Foam::sensibleEnthalpy>] in file /home/ubuntu/OpenFOAM/OpenFOAM-4.1/src/thermophysicalModels/specie/lnInclude/thermoI.H at line 66. FOAM aborting #0 Foam::error::printStack(Foam::Ostream&) at ??:? #1 Foam::error::abort() at ??:? #2 Foam::heRhoThermo >, Foam::sensibleEnthalpy> > > >::calculate() at ??:? #3 Foam::heRhoThermo >, Foam::sensibleEnthalpy> > > >::correct() at ??:? #4 ? at ??:? #5 __libc_start_main in "/lib/x86_64-linux-gnu/libc.so.6" #6 ? at ??:?

24 March 2021 0 0 View