Is there anything similar to a simulation that starts with a random genetic code and some genes that are translated into aaRS proteins which change the genetic code because the new aaRS aren't the same as the ones generated by the previous translation?
Is there literature about how the genetic code got stable? (stable means each codon has just one translation)
Thanks in advance.
Actually, in my opinion, there is a substantial record on just the opposite - that the genetic code has still been evolving and is not stable. However, if analyzing these phenomena, one can conclude about how the genetic code has been conserved (at least to the degree it has been, at all)). It may concern in particular the phenomenon of codon bias; see: Sharp & Lee, Nucl. Acid Res. 1987; 15(3) 1281 (this one you must know well); Kudla et al., Science 324, 255 (2009); DOI: 10.1126/science.1170160; Buhr et al., Mol Cell. 2016 February 4; 61(3): 341–351. doi:10.1016/j.molcel.2016.01.00; Article Exposing synonymous mutations
As to POLYSEMOUS (SIC!) codons, there is an interesting paper (quite an old one) showing that the genetic code is not set absolutely, and it keeps evolving: Suzuki et al., The EMBO Journal Vol.16 No.5 pp.1122–1134, 1997
I hope tnis is at least a little of what you need. I thing the codon bias (preference) is the main evolutionary force, in particular if you join it with the phenomenon of polysemous codons. A lot to think on, isn't it?
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