To separate an impurities from any raw materials by utilising the laboratory, Which practically methods are better ?All advanced facility such as H-NMR spectroscopy, GC mass and HPLC are very good but no all universities have them.
Hello sir, If I get it correctly you are asking for a non-instrumental setup, or relatively simple instrumentation. You may consider flash chromatography. You can find different methods of how to do it on the web like this one: https://yvesrubin.files.wordpress.com/2011/03/flash_chromatography.pdf
Regards
you can separate impurities by column chromatography like flash chromatography as Erhan said, other thing is you separate by using prep HPLC
Hello
Use simple separation techniques, such as:
1- Extraction (Liquid-Liquid or Solid-Liquid)
2- Evaporation then distillation (if your impurity is easily volatile such as a hydrocarbon).
3- Solid Phase Extraction (SPE), all you need is a vacuum manifold and the SPE cartridges.
4- Phase separation (if you have two liquids which are immiscible)
It would be more helpful for us to recommend a technique for you if you state your problem including the process, the compound of interest and the impurities.
Good luck
Hello Mukhtar A Kareem,
A microwave technique has utilized to preparation of 4-amino-5-(p-nitrophenyl)-1,2,4-Triazole-3-thiol via reaction between 5-(p-nitrophenyl)-1,3,4-Oxadiazole-2-thiol and hydrazine hydrate.Therefore, the process released some impurities such as the starting material and 4-amino-5-(p-aminophenyl)-1,2,4-Triazole-3-thiol because of reduction reaction of some Notre groups.
Regards.
In attempting to separate impurities from a sample, it is first necessary to identify what the properties of the materials that you want to measure in the sample, and the properties of the impurities that you want to separate out of the sample. Then identifying the rough concentrations of the materials to identify Only after doing this is it possible to come to a reasonable approach to separating the sample and the impurity. After doing this, then looking to the literature to see how it was done previously is the simplest and easiest path.
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