Hello,
I'm trying to fabricate PDMS chips to produce double emulsion and core-shell particle (PCL, PLGA..), but I'm struggling with the hydrophilic coating of specific region of my chip.
I've tried 1% PVA (9-10k 80% hydrolysed) injection after plasma bonding, and LbL technique with NaOH activation and PAH/PAA solution injection (10min NaOH, 5min each poly electrolyte, using syringe induced vacuum).
But when I try to produce simple W/O/W emulsion with DI Water / Hexadecane 2%Span80 / DI Water 2%PVA, wetting occured in the several chips, either at the W/O intersection or O/W intersection. My coating might be not really precise spatially, or not good enough.
Does anyone have experience with double emulsion/polymeric double emulsion production in PDMS chip and have advice or a method to help me ?
I can't use capillary microfluidics (I don't have the material) and my chips are made from molds drilled in PMMA substrate, so my dimension are limited to a 100 microns at the flow focusing intersection.
Many thanks for your help,
Best,
Romain
Hi Romain Guyon ,
I fabricated PDMS based microfluidic device for preparing w/o/w based core shell nanoparticles using a slightly modified device design as mentioned in this article.
Article Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic...
For coating, you can try using perfluorodecyl trichlorosilane (FTDS) after plasma bonding. Good luck..
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