The superiority of nanoemulsions versus self-microemulsifying drug delivery systems (SMEDDS) in terms of improving drug bioavailability depends on the specific drug and desired formulation characteristics. Both nanoemulsions and SMEDDS are colloidal drug delivery systems that are designed to improve the bioavailability of poorly soluble drugs.
Nanoemulsions are suspensions of small droplets of one liquid dispersed in another immiscible liquid, and they have a large surface area and a high drug-loading capacity, which makes them suitable for delivering high doses of drugs. They are also highly stable and have a long shelf-life, which makes them a suitable option for storing and transporting drugs. However, nanoemulsions can be challenging to formulate and may require specialized equipment and expertise to prepare.
SMEDDS, on the other hand, are a type of self-emulsifying drug delivery system that are designed to form a homogeneous solution in the gut, which improves the solubility and dissolution of poorly soluble drugs. SMEDDS are easy to administer, as they can be taken directly by mouth without the need for further dilution or processing. They are also highly bioavailable, as they form a homogeneous solution in the gut, which increases the solubility and dissolution of the drug.
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