I'm planning to use these peptides in a study on type 2 diabetes mellitus (T2DM). Does anyone know the key differences between [Pyr1]-Apelin-13 (HY-P1033) and Apelin-13 TFA (HY-P1944A)? I'm really torn on which one to choose...
There is no literature directly comparing the biological activities of these peptides. Apelin-13 TFA (HY-P1944A, MCE) is the primary native form of apelin, while [Pyr1]-Apelin-13 (HY-P1033, MCE) is a modified form of apelin-13 in which the first amino acid (proline, Pro) is replaced with pyroglutamic acid (Pyr). Modifications can result in differences in function and activity. You should consult the literature for your specific experimental needs. Currently, MCE sells Apelin-13 TFA (HY-P1944A, MCE) that is approved in the published literature by many customers.
The answer to this question comes from MedChemExpress (MCE) Technical Support.
- From the chemist's point of view, if the location of Pro or Pyr is N-terminal and it is not close to the active site, the desired mode of action could be expected to be similar. This replacement can, however, add stability, which then increases the bioactivity. However, Pro and Pyr are slightly different in their chemical structure, and this may nevertheless have some unpredictable impact in functional and activity differences.
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