There are two primary ways for XRD analysis. One is for single crystals another is for powder samples.

Thin films can have unidirectional growth for careful sputtering or CVD, PLD, ALD etc techniques. On the other hand, chemical methods like sol-gel, spin coating or dip coating of dispersed nanoparticles etc can produce thin films having radom crystallite or growth-direction. Accordingly, the XRD instrument has to be chosen and thereby analysis (e.g., Rietveld analysis) could be done.

Why don't you use power sample for XRD as nanoparticle film does not make a difference.

Muhammad Shahbaz Anwar, I have only 30 mg of sample and in powder XRD approx. 1g of sample is required.

Souvik Bhattacharjee Is single crystal and powder sample analysis make a difference? Can I go through the single crystal for nanoparticle analysis??