I want to synthesis a molecule based on a published paper, in the experimental section, the author said "......5 g silica and 2 drops of dibutyltindilaurate were added, and the mixture was heated at 60 C for 1 h. The silica was removed by filtration and the chloroform in resulting solution was removed in vacuo......". So, which kind of silica should I choose for this reaction? the silica gel for column chromatography? fumed silica? or other.
Thanks in advance!
Fumed silica is not a viable choice if silica is removed by filtration. It suggests that crystalline silica be employed.
Dear Yang Zhou many thanks for sharing this interesting technical question with the RG community. Apparently in this reaction the silica acts as a catalyst. Thus my suggestion would be to use just the common silica which is normally employed for column chromatography. This will be easily removed by filtration after the reaction. Good luck with your work and best wishes!
Sodium silicate from SiO2 can be carried out by reacting SiO2 with NaOHthen Sodium silicate is hydrolyzed to form silicic acid which can be used for the reaction..
You can used fume silica. Beside this if you used sodium silicate you may first extract silica by simple titration vis 3 molar of nirtic acid untile pH 3.
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