Which kind of ion pair agent for determination of paracetamol impurities would be the best option in mobile phase?

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Luiz Querino Caldas

Would not be simpler to extract these impurities using an ion-exchange technique? Perhaps , these old fashion methods could help you most.

Tania Sultana

Hello!

Dear Mr. R M Bazai,

I think the BP method for analysis of Paracetamol impurities is quite simple where they fixed the amount of Methanol in mobile phase.

Thanks,

Tania

Bruce Neagle

Why? Nobody uses ion pairing agents anymore with 'new' C18 columns with a high Carbon load.