Can an one give me article for reaction 4-hydroxy or 4- amino acetophenone and thiourea in the presence of IODINE as solvent can instead of iodine in other solvent such as ethanol .......
Dear Shaima Ibraheem Chyad Al-khazraji many thanks for sharing this very interesting chemical question with the RG community. I assume that you followed the protocol described in the following literature reference:
Synthesis and Characterization of Heterocyclic Compounds Derived From 4- Hydroxy and 4-Amino Acetophenone
Article Synthesis and Characterization of Heterocyclic Compounds Der...
This paper is freely available as public full text on RG. Here the synthesis of the 1,3-thiazole is not done in "iodine as solvent" but the reaction is carried out in the presence of iodine without any solvent. Thus you have essentially a melt reaction. This should be perfectly OK and is certainly worth a try. The same reaction is also described in the following article:
Synthesis and Spectroscopic Identification of a New Series of 2-Iminothia-zolidin-4-one Compounds from Aromatic Heterocyclic Primary Amines
Conference Paper Synthesis and spectroscopic identification of a new series o...
Here the reaction is also carried out in the melt without the use of any solvent.
Good luck with your work and best wishes, Frank Edelmann
Thankyou Dr .frank T.Edelmann
I need another article uses instead of iodine another starting material.
Dear Shaima Ibraheem Chyad Al-khazraji many thanks for your kind response and explanation. What is the problem with iodine? Is it too expensive? In any case, there are alternative synthetic routes to 1,3-thiazole derivatives which don't require the use of iodine. For a valuable overview of the different methods please have a look at the following review article:
An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
Article An Overview of the Synthesis and Antimicrobial, Antiprotozoa...
The good thing about this article is that it has been posted by the authors as public full text on RG. Thus you can freely download it as pdf file. You can also contact the corresponding author directly via RG at https://www.researchgate.net/profile/Oniga-Ovidiu and discuss your question with him. Just send him a personal message.
Good luck with your work and best wishes, Frank Edelmann