I obtain the TGA data of polymers and polymers+drug. How much information may I get from there ? Want to utilize the maximum application. Thanks.
Tushar... TGA from the definition is an accurate measure for the weight losses from a sample during heating. The individual polymer will exhibit its thermal stability and the extent of weight loss and the temperature interval of the loss. The heating rate is important to determine the TG profile of a sample. Being within the drug formulation, unless the drug material decompose in the vicinity of the polymer decomposition, the TG signal will show the decomposition behavior of the two components. But definitely, TG will give you first the loss of water molecules or any humidity that may affect the acceptability of the formulation. I can help in the explanation of your TG signals if may send them to me...... Good luck
Thank you M.M. Barbooti for your answer.
I will send you the files.
Kind Regards.
I would say you can do much more than thermal stability and weight loss for your polymer+drug samples.
1. You could perform a TGA to find out the kinetics of decomposition of your samples.
2. The life time prediction of your samples(Drug and polymer+Drug) could be found out. In a way you are arriving at the shelf life of your drug.
3. With the weight loss you can actually arrive at the molecular structure of the chemical species decomposition at a particular temperature.
For kinetic experiments, all you need is 3 TGA runs with different heating rates. After that there are many kinetic models available for you to get Ea, Half life, %Conversion, lifetime etc. One such model is Flyn-wall model.
Good luck!!!
Thanks Kannan MP.
It will be great if you give me some references or help me to find out those as i am new in TGA technique.
Regards.
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