Which genetic disease express founders effect among Nigerians?

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What is the cuurent trend on prostate immunohistochemistry for prostate cancer diagnosis?

we need to hear from the experts their experience on the field. thanks

08 January 2019 3,597 4 View

Camellia sinensis (green tea) and prostate cancer

please can someone help me with a source of of getting the above named leaves for use in on on going study on prostate cancer cell lines.

01 January 1970 5,429 2 View

What specific marker should we assay for to establish a link between Female genital schistosomiasis and cervical cancer?

tumor markers for fgs histochemistry

01 January 1970 3,197 4 View

I got 02 moderator values defining Johnson-Neyman significance regions. Is it an error?

Hi everyone, I am conducting research for my Master's thesis. I am using PROCESS by Johnson-Neyman to analyze my Moderator model. I test the relationship between Public Service Motivation and...

03 March 2021 2,350 2 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

Is it necessary to report effect size (ES) in statistics of biomedical research given that we already report p values routinely?

Pls share your thoughts

01 March 2021 7,330 4 View

How to eliminate Steady state error from Reinforcement learning genetic algorithm code?

The following code (see 1st 2 images attached) is used to produce PID controller values that are designed to control the system (G). The code finds the PID controller values (noted as k) by using...

28 February 2021 6,560 14 View

How to handle studies which report perfect effect sizes in a meta-analysis using Pearson's r?

I'm in the process of updating a meta-analysis and in one of the new studies, effect sizes are reported as Tau-U. Two of the effect sizes are reported as Tau-U = 1.00. I am using Andy Field's...

24 February 2021 2,265 3 View

Errors in DNA sequences?

I am trying to better understand the scope of DNA replication and sequencing errors, e.g. 1. I have seen similar error rates of 10e4 to 10e5 for cell & instrumental DNA replication,...

24 February 2021 4,397 3 View

How to constrain genetic algorithm input u?

My real system (buck converter) can only take an input of 0 to 1 (duty ratio) and I need to constrain the system so the controller action keeps within this bounds. How can I do this? The code for...

22 February 2021 2,125 3 View

How to perform EEG classification of Alzheimer and control groups?

I am doing a project on classification of EEG signals of Alzheimer's disease and control groups. Previously, I extracted the alpha power of the EEG signals and found out the strengths. I want a...

18 February 2021 8,502 2 View

How to deal with different types of logarithmic data for meta-analysis?

Hello dear researchers, 1.I want to know how can I compute pooled effect size when we have three types of logarithmic Mean&SD Type 1. Log (x) with base 10 Type 2. Ln (x) Type 3. Just...

18 February 2021 8,214 3 View

Choice of Ab for Co-IP: Does an anti-(tag) antibody (such as anti-flag/ anti-myc) a must if I am using co-transfected cells for Co-IP?

Hi guys, I am trying to detect the binding of 2 proteins by Co-immunoprecipitation. However, the choice of antibody is confusing me. I tried probing the endogenous protein right away but the...

16 February 2021 9,050 5 View

Christian G Meyer

Please check the following papers:

Cabral WA et al.: A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med. 2012 May;14(5):543-51. doi: 10.1038/gim.2011.44. Epub 2012 Jan 26.

Jacobson DR et al. The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa.

Mol Genet Genomic Med. 2016 Jul 14;4(5):548-56. doi: 10.1002/mgg3.231. eCollection 2016 Sep.

Zhang B et al. Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry.

Fam Cancer. 2009;8(1):15-22.

Dafydd Gareth Evans

Paper just out in J Clin Oncol By Olufunmilayo Olopade's group from the University of Chicago on over 1000 Nigerian women with breast cancer showed founder effect for oldest African BRCA1 mutation BRCA1 p.M1775R

Sumitha Elayaperumal

sickle cell anemia, breast cancer, "

Medical genetics and genomic medicine in Nigeria