Which genetic disease express founders effect among Nigerians?

More Imeobong Inyang's questions See All

Apart from Scopus, scimago and Web of Science which other indexing is relevant in a good journal for publication ?

23 July 2023 8,820 1 View

Can effective project management limit the risks associated with the successful application of SCM project?

A 10,000 words research paper using a survey methodology

02 June 2023 4,551 2 View

Does activated charcoal have any action in the rumen. How does it have affect degradation?

I Wish to know the mechanism of action of activated charcoal in the rumen of ruminants. How do they affect degradation and digestion.

25 May 2021 4,669 3 View

Which is the best method to use in retaining component in PCA?

I want ti#o know the best method to use in determining the number of component to retain in Principal component analysis. Between the Kaiser rule, Scree plot and parallel analysis, which is the...

20 April 2019 8,812 1 View

What is the cuurent trend on prostate immunohistochemistry for prostate cancer diagnosis?

we need to hear from the experts their experience on the field. thanks

08 January 2019 3,683 4 View

@KOU HAYAKAWA. is it better boiled stony mozuku as research subjects for the rattus norvergicus induced with high dos testosterone?

owing to export related issues the shipping company is requesting whether a cook muzuku cool be useful as the high metallic content of the fresh muzuku prevents its export.

28 December 2018 8,839 0 View

I have interest in cosmetic surgery as a gynecologist. How can i get those CDs or tutorials on how to perform cosmetic surgeries?

Cosmetic surgery

10 November 2011 6,023 1 View

Effect of ChatGpt on Research Students

With the way AI is impacting all aspects of our lives today, do we think that ChatGpt will not one day help a student to write his or her full reseach work. If this happens how will the...

01 January 1970 3,187 5 View

Camellia sinensis (green tea) and prostate cancer

please can someone help me with a source of of getting the above named leaves for use in on on going study on prostate cancer cell lines.

01 January 1970 5,510 2 View

What specific marker should we assay for to establish a link between Female genital schistosomiasis and cervical cancer?

tumor markers for fgs histochemistry

01 January 1970 3,250 4 View

Is an invitation to join the editorial board of Clinical Cardiology Updates a scam?

I received an e-mail invitation to join the editorial board of Clinical Cardiology Updates. While I have published a few articles related to cardiovascular disease, there are lots of colleagues...

06 August 2024 8,981 8 View

In the situation below, can I apply braun and Clark thematic analysis?

I have a theoretical framework for preparing a interview guide to assess the unmet care needs of a sub population of chronically ill patients and their caregivers(dyadic interviews).

04 August 2024 8,798 7 View

How to calculate effect size of AMCE (Average Marginal Component Effect) in Randomized Conjoint Experiment?

I am following Hainmueller, Hopkins, and Yamamoto's (2014) paper for my randomized conjoint experimental data analysis. The link to the paper is provided below. I received a comment from the...

02 August 2024 4,406 0 View

How are aPTT and PT values reduced after hemodialysis compared to before dialysis value in patients with chronic kidney disease?

I am conducting my research regarding blood coagulation in patients with CKD. I observed a reduction in post hemodialysis aPTT and PT values compared to pre hemodialysis values. But most of...

30 July 2024 3,467 0 View

How to conduct a sensitivity power analysis for Kendall's Tau?

Is there a straightforward way to conduct a sensitivity power analysis for a Kendall's Tau correlation? I was considering using the sensitivity setting and "Correlation: point biserial model" test...

28 July 2024 6,133 8 View

How can microbial engineering techniques be used to enhance the functionality and efficacy of probiotics ?

through genetic modification or metabolic engineering? Is it helpful, good for health ?

22 July 2024 7,811 4 View

What role does the gut microbiome play in immune system modulation and disease susceptibility?

Only Probiotics Related

22 July 2024 6,454 0 View

Getting standard errors and T-statistics for Dynamic panel data with instrumental variable method?

Dear all, I have a user written estimation code based on the paper dynamic panel data estimations with fixed effect by Galvao(2009). I have seen many papers using this method and pvalue, standard...

22 July 2024 4,588 1 View

How can i generate a CRISPR knockin mutation zebrafish model with a reporter?

Hey! I aim to generate a transgenic knockin zebrafish line that mimetizes a genetic condtition that leads to a certain disease on human. To do so, I need to insert a codon for mutagenic aminoacid...

14 July 2024 6,240 0 View

What would you do next?

Studying a specific monogenetic disease based on mutations in different individual genes. I try to recreate the disease phenotypes of donors in vitro. I knocked out a gene x with above 90%...

12 July 2024 6,313 0 View

Christian G Meyer

Please check the following papers:

Cabral WA et al.: A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med. 2012 May;14(5):543-51. doi: 10.1038/gim.2011.44. Epub 2012 Jan 26.

Jacobson DR et al. The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa.

Mol Genet Genomic Med. 2016 Jul 14;4(5):548-56. doi: 10.1002/mgg3.231. eCollection 2016 Sep.

Zhang B et al. Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry.

Fam Cancer. 2009;8(1):15-22.

Dafydd Gareth Evans

Paper just out in J Clin Oncol By Olufunmilayo Olopade's group from the University of Chicago on over 1000 Nigerian women with breast cancer showed founder effect for oldest African BRCA1 mutation BRCA1 p.M1775R

Sumitha Elayaperumal

sickle cell anemia, breast cancer, "

Medical genetics and genomic medicine in Nigeria