What do you mean with "aggressive"? More radioresistant, higher motility or higher proliferation rate? I think it depends on your purpose...

Hi,

Radaelli and us have published comparative studies of U87 and U251 models in vivo, especially on their hypoxic status.

Maybe these publications can help you :

http://www.ncbi.nlm.nih.gov/pubmed/19475534 http://www.ncbi.nlm.nih.gov/pubmed/23399636

http://www.ncbi.nlm.nih.gov/pubmed/19381449

I think that would also depend on what exactly you want to study and which signaling pathway? D54 GBM cells are pretty "aggressive".

Thanks everyone..I have got my expected cell lines