Which form of enalapril—enalapril sodium, enalapril maleate, or enalaprilat dihydrate—is most suitable for oral administration?

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I am currently conducting a research study and am interested in using enalapril as a positive control in my animal model (Wistar rats). Specifically, I am looking for a water-soluble form of enalapril that can be administered orally via drinking water (ad libitum) in rats. I found a few enalapril products available online, including enalapril sodium, enalapril maleate, and enalaprilat dihydrate.

1. Which of these forms (or any other available option) is the most water-soluble and stable for continuous administration in drinking water?

2. Recommended solvent and pH conditions for optimal solubility and stability.

3. Any available solubility data or formulation recommendations for preclinical animal studies.

Hongya Cheng

Enalapril sodium (HY-B0331B) and Enalapril maleate (HY-B0331A) are biologically equivalent, but not equivalent to Enalapril dihydrate (HY-B0231).

We recommend Enalapril maleate, which has good water solubility (33.33 mg/mL) and stability.

Recommended solvent: pure water, theoretically no need to adjust pH. We suggest that you adjust the specific conditions according to the experiment.

The answer to this question comes from MedChemExpress Technical Support.

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