Which factors or pathways regulates ETV1 expression?

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Robert Ancuceanu

Androgens seem to up-regulate ETV1 expression ( Article ETV1 Is a Novel Androgen Receptor-Regulated Gene that Mediat...

) and KIT ( https://www.nature.com/articles/nature09409). HER2/Neu seems to use PEA3 factors (including ETV1) as downstream effectors. BRAF might also be involved in its signalling, although from what I've read it may be speculative. Downregulation of CIC in SKMEL13 cells was associated with an increase in ETV1 expression. You may find a broader review here (

Article ETV1, 4 and 5: An Oncogenic Subfamily of ETS Transcription Factors

), but for a more focused one you could try writing one yourself.

Ido Lavi

Thank you very much!!