which factors do we need to consider while study of combining herbal extracts for analysis of Pharmacological screening?
Clinical/ preclinical reproduciblity of any polyherbal formulation is critical to achieve. Always refer the monographs given in Ayurvedic Pharmacopoeia of India before the development and during the standardization of such formulations.
Factors which are critical to ensure effectiveness, safety and reproducible may be
habitat, geographical and climate condition, harvesting condition, method of storage and its pharmaceutical processing.
Also is important to know the concentration of the pharmacological markers (actives molecules) of each extract. If you know the level of this molecules in yours extracts you will evidence the relation between the pharmacological effect and the concentration of the molecules, furthermore you will evidence negative or positive interaction between the extracts in an easier way.
how to find out the interaction or compatibility between extracts?
If you´re going to study any pharmacological activity, you first taste every extract per separate and the pharmacologicals markers too, all separate; this gets you the data of the activity for everything that you taste. Later, you combine the extracts quantificated for the pharmacological marker (the mixture of natural extracts) and tasted too. After that you will determinate positivite or negativite interaction. For example, if the biological activite increse when you taste the the mixture of extracts compared to the extracts tested separately, we talk about sinergism (positive interaction) but if the biological activity is less than the extracts tested separately, we talk about negative interaction. And how you tasted too the pharmacological markers you could establish the relationship between the concentration of the molecule and the biological activity.
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